The Hotel am Dom is located right at the heart of Frankfurt's old town. It is very easy to reach whether you arrive via public transport or by car. Along with underground stations, there is also car parking right near the hotel.
The historical old town as well as the museums right on the waterfront ("Museums-ufer") can easily be explored on foot.

Public Transportation:
One takes the S8 or S9 underground from the Frankfurt Airport to the main train station ("Hauptbahnhof"). From here one takes the U4 or U5 underground to the Römer station. The exit ("Domplatz") is right next to the hotel.
Alternatively one can take a regional train in the direction of Hanau and gets off at the south train station ("Frankfurt Süd"). From here one takes the U1, U2 or U3 underground to the Willy-Brandt-Platz and changes to the U4 or U5 to the Römer.
To get an overall view click here for the train and streetcar map.

Arriving by car:
Coming from the South take the A5 all the way to the Frankfurter Kreuz. The next exit will bring you to the B43 that leads directly to the center of Frankfurt.
Coming from the North take the A5 to the Nordwestkreuz and then change to the A66 in the direction of the Miquelallee. From here turn right on the Eschersheimer Landstrasse that ends at the center of town.
Coming from the West, take the A66.
Coming from the East take the A3 to the exit Frankfurt Süd and change to the B43 all the way into town.